Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growth. Here, we used a transgenic zebrafish model to show that Myf5 is sufficient ...

SREBP-1 Transcription Factors Regulate Skeletal Muscle Cell Size by Controlling Protein Synthesis through Myogenic Regulatory Factors

SREBP-1 are ubiquitously expressed transcription factors, strongly expressed in lipogenic tissues where they regulate several metabolic processes like fatty acid synthesis. In skeletal muscle, SREBP-1 proteins regulate the expression of hundreds of genes, and we previously showed that their overexpression induced muscle atrophy together with a combined lack of expression of myogenic regulatory ...

Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation

Precise regulation of gene expression is crucial to myogenesis and is thought to require the cooperation of various transcription factors. On the basis of a bioinformatic analysis of gene regulatory sequences, we hypothesized that myogenic regulatory factors (MRFs), key regulators of skeletal myogenesis, cooperate with members of the SIX family of transcription factors, known to play important ...

The Myogenic Regulatory Factors: Critical Determinants of Muscle Identity in Development, Growth and Regeneration

Myogenic Regulatory Factors Expressed During Postnatal Hy- perplastic Growth in Porcine Muscles

Muscle progenitors cells migrate from the somite to develop into primary and secondary myotubes due to the activation of a number of regulatory factors, which are classified as myogenic determination and differentiation factors (MRFs). The presence of a third generation of myotubes has been described in the sheep, human and bovine during foetal life whereas in pig they appear shortly after birt...